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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Curr Opin Microbiol. 2011 Apr 29;14(3):321–327. doi: 10.1016/j.mib.2011.03.005

Figure 2.

Figure 2

Combinations of Cas proteins create diverse CRISPR-Cas systems. Cas1-6 are core Cas proteins found in many and diverse organisms. In addition, there are eight primary modules of subtype-specific Cas proteins (consisting of 2–6 proteins each), and the auxiliary Cmr module. A typical CRISPR-Cas system is comprised of the nearly universal Cas1 and Cas2 proteins, a specific combination of the other core Cas proteins and a set of sub-type specific Cas proteins. A given organism may possess more than one CRISPR-Cas system, and may also have the Cmr module. See Haft et al. [29].