Table 3.
Significant voxels in the cerebellar, brainstem, and limbic tracts identified by TBSS analysis
| HC > PFX+ | PFX- > PFX+ | Negative correlation with FXTAS Score | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| x | y | z | P | Volume (mm3) | x | y | z | P | Volume (mm3) | x | y | z | P | Volume (mm3) | |
| Cerebellar and brainstem tracts | |||||||||||||||
| MCP | 33 | -50 | -40 | 0.002 | 1085 | N.S. | 32 | -52 | -43 | 0.033 | 71 | ||||
| R. Superior cerebellar peduncle | 10 | -51 | -31 | 0.011 | 171 | N.S. | N.S. | ||||||||
| L. Superior cerebellar peduncle | -6 | -53 | -31 | 0.010 | 190 | N.S. | N.S. | ||||||||
| R. Inferior cerebellar peduncle | 11 | -45 | -34 | 0.011 | 122 | N.S. | N.S. | ||||||||
| L. Inferior cerebellar peduncle | -6 | -54 | -21 | 0.010 | 144 | N.S. | N.S. | ||||||||
| Pontine crossing tract | 7 | -29 | -30 | 0.019 | 31 | N.S. | N.S. | ||||||||
| R.Cerebral peduncle | 9 | -7 | -7 | 0.005 | 369 | N.S. | 15 | -10 | -6 | 0.022 | 123 | ||||
| L.Cerebral peduncle | -19 | -21 | -7 | 0.0002 | 253 | N.S. | -18 | -21 | -5 | 0.007 | 93 | ||||
| R.Corticospinal tract | 4 | -20 | -32 | 0.014 | 215 | N.S. | N.S. | ||||||||
| L.Corticospinal tract | -5 | -18 | -24 | 0.012 | 51 | N.S. | N.S. | ||||||||
| R. Medial lemniscus | 7 | -39 | -28 | 0.011 | 110 | N.S. | N.S. | ||||||||
| L. Medial lemniscus | -6 | -39 | -28 | 0.011 | 81 | N.S. | N.S. | ||||||||
| Limbic tracts | |||||||||||||||
| Fornix | 2 | -13 | 15 | 0.0002 | 78 | 1 | -4 | 9 | 0.036 | 67 | 1 | -5 | 9 | 0.01 | 87 |
| R. Cingulum (hippocampal levels) | 25 | -29 | -12 | 0.0004 | 85 | 13 | -47 | 7 | 0.029 | 10 | 14 | -45 | 7 | 0.0004 | 208 |
| L. Cingulum (hippocampal levels) | -15 | -46 | 1 | 0.0002 | 253 | -14 | -43 | 2 | 0.026 | 17 | -11 | -45 | 2 | 0.0004 | 221 |
| R. Fornix/Stria terminalis | 31 | -26 | -10 | 0.0002 | 119 | N.S. | 31 | -22 | -8 | 0.016 | 208 | ||||
| L. Fornix/Stria terminalis | -23 | -35 | 2 | 0.0002 | 159 | -25 | -35 | 2 | 0.028 | 9 | -28 | -25 | -10 | 0.004 | 143 |
HC = healthy control, PFX+ = premutation carriers with FXTAS, PFX- = premutation carriers without FXTAS, MCP = middle cerebellar peduncle, L = Left, R = Right, N.S. = No significant voxel was identified.