Table I.

Affymetrix microarray expression data in lupus LDGs of genes corresponding to enzymes, bactericidal and other molecules known to be implicated in ROS generation and/or NET formation.

			Lupus LDGs compared to control neutrophils		Lupus LDGs compared to lupus neutrophils
Entrez gene ID	Gene symbol	Gene name	Fold-change	q-valuea	Fold-change	q-valuea
Enzyme and enzyme inhibitor genes
6036	RNASE2	Ribonuclease, RNaseA family, 2 (liver, eosinophil-derived neurotoxin)	4.24	0.004*	3.06	0.066
4317	MMP8	Matrixmetallopeptidase 8 (neutrophil collagenase)	38.53	0.000*	41.53	0.000*
4318	MMP9	Matrix metallopeptidase 9 (gelatinase B,92 kDa gelatinase,92 kDa type IV collagenase)	1.08	0.999	1.37	0.047*
6037	RNASE3	Ribonuclease, RNase A family, 3 (eosinophil cationic protein)	12.34	0.000*	12.07	0.000*
1991	ELANE (Elastase 2)	Elastase, neutrophil expressed	11.64	0.000*	10.92	0.000*
3934	LCN2	Lipocalin2	24.49	0.000*	19.02	0.000*
5476	CTSA	Cathepsin A	1.69	0.004*	1.54	0.043*
1511	CTSG	CathepsinG	13.53	0.000*	17.73	0.000*
4353	MPO	Myeloperoxidase	12.02	0.000*	14.66	0.000*
Bactericidal molecule genes
1669	DEFA4	Defensin, alpha 4, corticostatin	22.41	0.000*	25.57	0.000*
820	CAMP (LL-37)	Cathelicidin antimicrobial peptide	3.44	0.003*	4.62	0.000*
671	BPI	Bactericidal/permeability-increasing protein	13.80	0.000*	16.59	0.000*
566	AZU1	Azurocidin 1	11.23	0.000*	12.22	0.000*
Other genes
1088	CEACAM 8 (CD66b)	Carcino embryonic antigen-related cell adhesion molecule8	16.63	0.000*	18.27	0.000*
10321	CRISP3	Cysteine-rich secretory protein3	18.39	0.000*	12.18	0.000*
634	CEACAM 1 (CD66a)	Carcino embryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	1.50	0.099	1.30	0.017*
4057	LTF	Lactotransferrin	16.91	0.000*	12.01	0.000
1191	CLU	Clusterin	21.24	0.000*	17.39	0.000*

^aA q-value below 0.05 was considered as significant (in bold and with asterisk); N/A: not expressed above the Affymetrix control baseline.