TABLE 2.
Effects of adenosinergic drugs on PPI and its disruption by psychostimulants: MSX-3 (((E)-phosphoric acid mono-[3-[8-[2-(3-methoxyphenyl)); the full names of the other drugs are provided in Table 1. ↓ / ↑: attenuates / potentiates basal PPI or the drug-induced PPI disruption; ↔ no effect.
| • Adenosinergic drugs on Sensorimotor gating measured by prepulse inhibition (PPI) | |||
|---|---|---|---|
| Adenosinergic drugs | Adenosinergic action | Effect | References |
| CPA | A1R agonist | ↔ | Sills et al., 1999 |
| Schwienbacher et al., 2002 | |||
| CGS21680 | A2AR agonist | ↔ | Hauber and Koch, 1997 |
| Sills et al., 2001 | |||
| Caffeine | A2AR antagonist | ↔ | Bakshi et al., 1995 |
| MSX-3 | A1R/A2R antagonist | #x2193; | Nagel et al., 2003 |
| Theophylline | ↔ | Koch and Hauber, 1998 | |
| ↓ / ↑: impairs / enhances PPI; ↔ no effect | |||
| • Adenosinergic drugs against psychostimulant-induced ppi deficit | ||||
|---|---|---|---|---|
| PPI-disrupting agents | Adenosinergic action | Adenosinergic drugs | Effect against PPI disrpution | References |
| Amphetamine | A2AR agonist | CGS 21680 | ↔ | Sills et al., 2001 |
| Apomorphine | A1R agonist | CPA | #x2193; | Koch and Hauber, 1998 |
| A2AR agonist | CGS 21680 | #x2193; | Hauber and Koch, 1997 | |
| ↔ | Sills et al., 2001 | |||
| A1R/A2R antagonist | Theophylline | ↑ | Koch and Hauber, 1998 | |
| MK-801 / PCP | A2AR agonist | CPA | #x2193; | Sills et al., 1999 |
| A2AR agonist | CGS 21680 | ↓ | Sills et al., 2001 | |
| Wardas et al., 2003 | ||||