Fig. 1. T. forsythia-induced cytokine expression in macrophages and dendritic cells is TLR2-dependent.
Inflammatory cytokine levels (A. IL-6 and IL-10; B. IL12p40, IL12p70, IL-23p19) were examined by ELISA in the supernatants of mouse DC’s and peritoneal macrophages from BALB/c and TLR2−/− mice following challenge with different agonists. The data show the means ± standard deviations of triplicate determinations in one of 3 independent sets of experiments that yielded similar results; statistically significant differences between the groups are indicated by asterisks (***, p<0.001; **, p<0.01; *, p< 0.05).