Table 2.

Trabecular and cortical μCT parameters in the left control and right loaded tibiae in mice treated with vehicle or risedronate at a dose of 0.15, 1.5, 15 or 150 μg/kg/day.

Dose of risedronate (μg/kg/day)	0 (n = 20)	0.15 (n = 10)	1.5 (n = 10)	15 (n = 10)	150 (n = 10)	p valuea
						Risedronate	Loading	Interaction
Trabecular bone
Bone volume/tissue volume
Left control (%)	16.6 ± 0.3	17.1 ± 0.4	17.7 ± 0.3	20.9 ± 0.6	21.3 ± 0.4	< 0.001	< 0.001	0.655
Right loaded (%)	22.7 ± 0.5	22.6 ± 0.5	23.2 ± 0.6	26.4 ± 0.7	27.7 ± 0.8
Trabecular number
Left control (mm− 1)	3.02 ± 0.05	3.07 ± 0.08	3.26 ± 0.06	3.66 ± 0.10	3.60 ± 0.08	< 0.001	< 0.001	0.697
Right loaded (mm− 1)	3.38 ± 0.05	3.40 ± 0.10	3.53 ± 0.08	4.03 ± 0.10	4.04 ± 0.13
Trabecular thickness
Left control (μm)	55.1 ± 0.5	55.7 ± 0.8	54.4 ± 0.6	57.3 ± 0.8	59.2 ± 0.9	0.009	< 0.001	0.011
Right loaded (μm)	67.1 ± 0.6	66.5 ± 0.9	65.8 ± 1.0	65.5 ± 0.8	68.6 ± 1.1
Cortical bone
Bone volume
Left control (mm3)	0.380 ± 0.003	0.383 ± 0.003	0.366 ± 0.005	0.377 ± 0.007	0.372 ± 0.007	0.815	< 0.001	0.725
Right loaded (mm3)	0.481 ± 0.006	0.479 ± 0.006	0.476 ± 0.008	0.479 ± 0.009	0.481 ± 0.007
Periosteally enclosed volume
Left control (mm3)	0.627 ± 0.005	0.614 ± 0.006	0.594 ± 0.008	0.611 ± 0.011	0.607 ± 0.012	0.111	< 0.001	0.243
Right loaded (mm3)	0.717 ± 0.005	0.713 ± 0.008	0.709 ± 0.006	0.704 ± 0.010	0.709 ± 0.007
Medullary volume
Left control (mm3)	0.247 ± 0.003	0.231 ± 0.004	0.228 ± 0.005	0.234 ± 0.006	0.236 ± 0.007	0.096	0.085	0.030
Right loaded (mm3)	0.237 ± 0.004	0.234 ± 0.006	0.234 ± 0.005	0.226 ± 0.007	0.228 ± 0.005

Mean ± SE.

^aMixed model analysis including body weight.