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. 2011 Jun 9;7(6):753–761. doi: 10.7150/ijbs.7.753

Figure 3.

Figure 3

Overexpression of mutant LRRK2 impairs DA reuptake in aged rats. A, Intra-brain microdialysis revealed the extracellular levels of DA in the striatum of free-moving rats at 18 months of age. Basal DA release was established in living rats when three consecutive samplings resulted in a sustainable level of DA in dialysates in the absence of stimulation. The peaks of stimulated DA release were detected after nomifensine (200 µM) or amphetamine (1.3 mM) was applied to dialysate. Data are means ± SEM (n = 8). * p < 0.05 compared to CAG-tTA single transgenic rats (tTA). B, Increased peak of stimulated DA release was calculated for each animal by subtracting basal release from stimulated release. * p < 0.05 compared to either tTA single transgenic rats or constitutive LRRK2-expressing rats.