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. Author manuscript; available in PMC: 2011 Jun 22.
Published in final edited form as: J Biol Rhythms. 2010 Oct;25(5):372–380. doi: 10.1177/0748730410379711

Figure 5. DAVID analysis of cycling genes detected by JTK_CYCLE in NIH3T3 cells reveals a cluster of RNA-binding genes with similar phases.

Figure 5

JTK_CYCLE was used to re-analyze cycling transcripts in synchronized NIH3T3 cells (Hughes et al. 2009). JTK_CYCLE detected more than twice as many cycling transcripts (N=30) as previously reported. DAVID analysis was performed on these 30 transcripts to detect enriched functional classes. Among the most enriched groups was a cluster of eight genes involved in RNA binding and recognition (A). Green blocks indicate that the annotations on the x-axis are present in the genes on the y-axis. Of these eight genes, six show similar phases of their oscillations (B), suggesting a common underlying mechanism (the dotted line represents a moving average of the median-normalized expression patterns of all six transcripts).