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The effect of Cdh1 and Sic1 on ME. Simulations were started from a low Cdk1 activity G1-like state (grey, shaded area) and Cdh1 activation (kdcdh′ and kdcdh) or the rate of Sic1 synthesis (kssic′, kssic) were set to zero, which correspond to cdh1Δ (a) and sic1Δ (b). The combined effect of Cdh1 and Sic1 deletions (cdh1Δ sic1Δ) which blocks ME is shown in (c).
