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. Author manuscript; available in PMC: 2011 Jun 22.
Published in final edited form as: Org Lett. 2008 Mar 20;10(8):1605–1608. doi: 10.1021/ol800298n

Table 4.

Zinc(II) Triflate Catalyzed Mukaiyama-aldol Reactions of 1 with Representative Aldehydesa

graphic file with name nihms216646u5.jpg
entry aldehyde R % yield of 3 (ref 10)b % yield of 3 (this work)c
1d 2a C6H5- 93 97
2 2b trans-β-styryl 89 91
3 2c 4-NO2-C6H4- 0 80
4 2d 2-NO2-C6H4- 0 61
a

Same procedure as in Table 2.

b

Yield of isolated 3 from Sc(OTf)3 catalyzed aldol reaction, see reference 10 for detail.

c

Yield of isolated 3 following column chromatography.

d

Use of 0.2 mol % Zn(OTf)2 gave a 97% yield of 3a; use of 0.1 mol% Zn(OTf)2 gave 92% yield of 3a.