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The role of syndecan-4 in focal adhesion. (A) Fibroblasts attach and spread through α5β1 integrin on coverslips coated with the integrin-binding domain of fibronectin but they do not form focal adhesions. (B) Focal adhesions (arrows) form only after engagement of syndecan-4 HS chains after the addition of the heparin-binding domain (HepII) from fibronectin. (Data for image from Okina et al. 2009.)
