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. 2011 Jul;3(7):a002592. doi: 10.1101/cshperspect.a002592

Figure 2.

Figure 2.

DNA methylation is essential for establishment and maintenance of imprinting. Shown are the two types of DNA methylation present at imprinted loci. (A) Greater than 16 imprinted loci are associated with maternal-specific methylation. For these loci, DNA methylation (filled lollipops) is associated with the promoter of a repressed gene, whereas hypomethylation (gray lollipops) is associated with the promoter of the expressed gene (arrow). (B) Four imprinted loci are associated with DNA methylation in intergenic regions. In one case (H19 and Igf2), the DNA methylation regulates a CTCF-dependent insulator element (see text).