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. 2011 Jul;3(7):a007559. doi: 10.1101/cshperspect.a007559

Figure 2.

Figure 2.

Chaperone systems in the mitochondrial matrix. mtHsp70 drives the import of nuclear encoded preproteins through the TOM and TIM (translocases in the OM and IM, respectively). In addition, mtHsp70 facilitates protein folding, although some proteins require an additional chaperonin complex, Hsp60/10, to fold. Stress-induced unfolding renders proteins prone to aggregation. The Hsp78 chaperone acts as a disaggregase and in conjunction with mtHsp70 can restore a proteins tertiary structure. OM, mitochondrial outer membrane; IMS, mitochondrial intermembrane space; IM, mitochondrial inner membrane; I–V, respiratory chain complexes, ROS, reactive oxygen species.