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. Author manuscript; available in PMC: 2012 Apr 22.
Published in final edited form as: Chem Biol. 2011 Apr 22;18(4):508–519. doi: 10.1016/j.chembiol.2011.01.019

Figure 1. Prenylagaramide Gene Cluster from Planktothrix agardhii.

Figure 1

Figure 1

A. Genetic organization of the pag cluster and sequences of all pag precursor peptides. Black: precursor peptides. Blue: N-terminal protease. Light green: C-terminal protease / macrocyclase. Amino acid sequences of prenylagaramide B and C are boxed, prenylated Tyr residues are highlighted in blue while the actual or predicted C-terminal cleavage site Pro is highlighted in red. Asterisks indicate 100% conservation among variants. Light blue-highlighted sequences indicate the more conserved N- and C-termini of the peptides versus the hypervariable inner region. B. Prenylated tyrosine residues are highlighted in blue. Structures and HRFTMS and IRMPD-MS/MS analysis of prenylagaramide B (Murakami et al., 1999) and C showing the molecular ion and the loss of one isoprenyl group. For 2, the indicated configuration is predicted based upon biogenetic considerations and on the structures of other compounds in the series. See also Table S1 and Figure S1.