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. Author manuscript; available in PMC: 2012 Apr 22.
Published in final edited form as: Chem Biol. 2011 Apr 22;18(4):508–519. doi: 10.1016/j.chembiol.2011.01.019

Table 2. Analysis of the open reading frames in art.

Proteins highlighted in grey are known to be associated with cyanobactin biosynthesis. Str.2 = Arthrospiraplatensis str. Paraca, Str.3 = Arthrospira sp. PCC 8005, P = partial hit due to incomplete sequencing.

Predicted Protein Best Cyanobactin Hit % Identity Predicted Function Organism Str. 2 Str. 3
ArtA MicA 73% N-terminal protease Microcystis aeruginosa PCC 7806 98% 100% P.
ArtB TruB 63% Unknown Prochloron didemni 99% 100%
ArtC TenC 58% Unknown Nostoc spongiaeforme var. tenue 98% 100%
ArtD TenD 73% Heterocyclase Nostoc spongiaeforme var. tenue 96% 100%
ArtE1 TenE 53% Precursor peptide Nostoc spongiaeforme var. tenue NO NO
ArtE2 TenE 52% Precursor peptide Nostoc spongiaeforme var. tenue NO NO
ArtE3 TenE 54% Precursor peptide (Arthrospiramide A) Nostoc spongiaeforme var. tenue NO NO
ArtE4 TenE 69% P Precursor peptide Nostoc spongiaeforme var. tenue NO NO
ArtE5 TruE1 55% Precursor peptide (Arthrospiramide B) Prochloron didemni NO NO
ArtE6 PatE 55% Precursor peptide Prochloron didemni NO NO
Orf1 Acy-Orf5 71% Transposase Anabaena sp. 90 80% P 100% P
ArtF MaeF 58% Unknown Microcystis aeruginosa NIES-843 95% 100%
Orf2 None 85% Conserved Hypothetical Protein Cyanothece sp. CCY0110 NO NO
Orf3 None 83% Transposase Microcystis aeruginosa NIES-843 NO 100% P
Orf4 None 87% Conserved Hypothetical Protein Arthrospira platensis NIES-39 NO NO
Orf5 Mic-Orf 87% Conserved Hypothetical Protein Microcystis aeruginosa PCC 7806 90% 100%
ArtG PatG 63% C-terminus protease / Macrocyclase Prochloron didemni 85% 100% P