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. Author manuscript; available in PMC: 2011 Jun 22.
Published in final edited form as: J Nucl Med. 2010 Jun 16;51(7):1092–1098. doi: 10.2967/jnumed.109.073361

FIGURE 1. In vivo metabolite analysis of 18F-FAC.

FIGURE 1

(A) Chemical structures of 18F-FAC and 18F-FAU and schematic showing the extracellular and intracellular routes by which 18F-FAC can be deaminated to 18F-FAU. CDA, cytidine deaminase; 5′-NT, 5′nucleotidase; DCTD, cytidylate deaminase (catabolic enzymes are shown in red fonts); (B) Percentage of total detected radioactivity in plasma that is attributable to 18F-FAC over time as determined by HLPC analysis. Analysis is carried out following intravenous injection of 18F-FAC in mice.