Skip to main content
. 2001 Mar 20;98(7):4184–4189. doi: 10.1073/pnas.061445598

Figure 6.

Figure 6

The GAL-tg mice failed either to learn or remember the environmental landmarks necessary to solve the Morris water maze memory task. GAL-tg mice (n = 11 males, 10 females) and WT controls (n = 16 males, 9 females) were tested for cognitive abilities on a spatial navigational task at 8, 16, and 24 months of age. WT mice showed selective search on the probe trial, whereas the GAL-tg did not. GAL-tg were not significantly different from WT controls on acquisition of the visible platform or hidden platform tasks. (A) Visible platform acquisition; (B) hidden platform acquisition; (C) swim speed; (D) thigmotaxis, swimming within 8 cm of the circumference of the pool, A–D at 16 months of age; (E) transfer test at 8 months of age; (F) transfer test at 16 months of age; (G) transfer test at 24 months of age. This highly specific deficit on the probe trials reflects an inability to learn and/or recall the association between the environmental room cues and the spatial location of the hidden platform. Data are expressed as the mean ± SEM; *, P < 0.05 compared with the trained quadrant.