Table 2.

Body size and hormone therapy use and risk of epithelial ovarian cancer in women age ≥ 45 years in the California Teachers Study cohort

	Never used HT				HT ≤ 5 years				HT > 5 years
	Cases	Person-years	RRa	95% CI	Cases	Person-years	RRa	95% CI	Cases	Person-years	RRa	95% CI
BMI (kg/m2)
<25	57	175,216	1.0	Reference	41	101,462	1.2	0.76, 1.8	64	88,130	1.8	1.2, 2.6
25–29	29	77,031	1.1	0.71, 1.8	21	46,700	1.3	0.74, 2.1	30	41,282	1.7	1.1, 2.8
≥30	21	48,237	1.2	0.72, 2.0	6	24,856	0.65	0.28, 1.5	8	16,507	1.1	0.53, 2.5
BMI at age 18 (kg/m2)
<25	90	263,607	1.0	Reference	57	154,751	1.0	0.71, 1.4	91	132,900	1.6	1.1, 2.2
≥25	16	32,733	1.4	0.82, 2.4	7	16,074	1.1	0.52, 2.5	9	10,986	1.9	0.94, 3.9
Weight change (since age 18)b
Loss, >10 lb	15	29,294	1.8	0.94, 3.5	9	15,187	2.0	0.90, 4.4	12	12,446	2.9	1.4, 6.1
Stable, ±10 lb	22	78,662	1.0	Reference	28	43,887	2.2	1.2, 3.9	31	38,541	2.3	1.3, 4.1
Gain, 11–39 lb	31	117,098	0.96	0.55, 1.7	17	71,428	0.81	0.42, 1.5	37	62,356	1.7	0.98, 3.0
≥40 lb	38	72,570	1.8	1.0, 3.0	13	41,293	1.0	0.51, 2.1	20	31,092	1.9	0.99, 3.5
Waist circumference (inches)
<35	32	113,564	1.0	Reference	29	69,763	1.4	0.83, 2.4	41	60,898	2.2	1.3, 3.6
≥35	29	52,592	1.8	1.1, 3.0	13	31,086	1.4	0.69, 2.6	22	28,210	2.4	1.3, 4.3
Waist-to-height ratio
<0.55	35	120,779	1.0	Reference	33	74,915	1.5	0.88, 2.4	42	65,405	2.0	1.2, 3.3
≥0.5 5	26	45,378	1.8	1.1, 3.1	9	25,935	1.1	0.52, 2.4	21	23,703	2.7	1.5, 4.9
Waist-to-hip ratio
<0.80	29	80,796	1.0	Reference	23	48,774	1.2	0.69, 2.2	25	38,331	1.6	0.88, 2.9
≥0.80	32	85,360	0.95	0.56, 1.6	19	52,076	0.90	0.49, 1.7	38	50,777	1.7	0.96, 2.9

HT hormone therapy, BMI body mass index, RR relative risk, CI confidence interval

^aAdjusted for race, oral contraceptive use and duration, number of full-term pregnancies, wine consumption, physical activity, smoking history, history of tubal ligation and height; age was the time-scale, and analyses were stratified by age at baseline

^bAdditionally adjusted for weight at 18