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. Author manuscript; available in PMC: 2011 Jun 22.
Published in final edited form as: Biol Psychiatry. 2010 Nov 11;69(7):704–707. doi: 10.1016/j.biopsych.2010.09.033

Figure 1.

Figure 1

Restriction of dopaminergic signaling to the striatum of vrDDDorsal and vrDD-Ventral mice. Tyrosine hydroxylase (TH) (red) immunostaining was visualized in coronal sections of the striatum from control and vrDD mice. (A) Schematic illustration of the Th-restoration strategy, depicting viral injections into the dorsal and ventral striatum of vrDD and control mice. (B) TH expression pattern in sham control mice. (C) TH expression found in vrDD-Dorsal mice. Expression was restricted to the dorsal striatum with strong immunostaining in both lateral and medial regions. (D) TH expression found in vrDD-Ventral mice. Expression was strongest in the nucleus accumbens with some immunostaining in the dorsomedial striatum and the olfactory tubercle.