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. Author manuscript; available in PMC: 2011 Jun 22.
Published in final edited form as: Biol Psychiatry. 2010 Nov 11;69(7):704–707. doi: 10.1016/j.biopsych.2010.09.033

Figure 2.

Figure 2

Cognitive flexibility by sham and vrDD mice. (A) Escape latencies and (B) percentage of correct trials/training day during pretraining of the turn-based strategy. Sham control, vrDD-Dorsal, and vrDD-Ventral mice reached > 80% correct trials on the third training day. Escape latencies by vrDD mice were elevated compared with sham control mice. (C) Escape latencies and (D) percentage of correct trials/training day during reversal-learning. Although vrDD mice performed slower than sham control mice, all groups reached > 80% correct trials on the fourth training day. (E) Escape latencies and (F) percentage of correct trials/training day during pretraining of the turn-based strategy. Strategy-shifting was impaired in vrDD-Ventral mice. Sham-control and vrDD-Dorsal mice reached > 80% correct trials on the third training day; vrDD-Ventral mice required 6 training days to reach this criterion. Significant main effects of group (**p < .01; *p < .05). Data are means ± SEM.