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Fraction of patients who developed AKI as a function of hypotension duration in the target 48-hour window using various MAP values as thresholds. A third of the 3613 patients included in this plot developed AKI, as indicated by the black dashed line. Prolonged hypotension increased the incidence of AKI in these patients. The duration of hypotension associated with a 5% increase in AKI incidence (indicated by the dotted blue line) varies with severity of hypotension (see text).
