Table 4.

Vinylogous Amidine Synthesis.

entry	ynamides	enaminesa	vinylogous amidines	yield [%]b
1	8a: R = Ts 8h: R = MBS	41	45 46	52c
2				71d
3	8f	42	47	58e
4	8d	41	48	54f
5	8i	41	49	57g
6	8j	43	50	--
7		42	51	62h

^aUnless otherwise noted, all reactions utilized 3.0 equiv of the enamine, 5.0 mol% Pd₂(dba)₃, and 10.0 mol% of xantphos; and were run in THF [conc = 0.05 M].

^bIsolated yields.

^c2 h at 70°C.

^d2 h at 50 °C with 1.5 equiv of K₂CO₃.

^e12 h at 70°C with 1.5 equiv of 42; 2.0 mol % Pd₂(dba)₃; and 4.0 mol% of xantphos.

^f30 min at 50 °C.

^g2 h at RT.

^h2 h at 75 °C with 1.5 equiv of K₂CO₃ and 1.5 equiv of 44.