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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Curr Opin Pharmacol. 2011 Feb 28;11(2):131–137. doi: 10.1016/j.coph.2011.02.001

Figure 3.

Figure 3

Signaling pathways interacting with angiotensin peptides in dorsal medullary cardiovascular nuclei. Proposed model: Ang-(1–7) up-regulates the MAPK phosphatase MKP-1 to attenuate Ang II-stimulated MAPK signaling pathways and ROS (from cytoplasmic, nuclear or mitochondrial sources), resulting in improved BRS and lower MAP. Abbreviations: ROS= reactive oxygen species, MAPK-p= phosphorylated MAPK, MAP= Mean arterial pressure, BRS= Baroreflex sensitivity