Table 2.
Multiple linear regression analyses with measured GFR as the dependent variable
| Independent variable | β Coefficient | 95% CI | P |
|---|---|---|---|
| Model 1 | |||
| BMI, per unit | 0.04 | −0.12 to 0.21 | 0.64 |
| Model 2 | |||
| Fasting glucose, per mmol/L (18 mg/dL) | 3.67 | 2.29–5.06 | <0.001 |
| Model 3 | |||
| HbA1c, per % unit | 2.38 | 0.46–4.31 | 0.015 |
| Model 4 | |||
| Fasting insulin, per μU/mL | 0.16 | 0.03–0.29 | 0.015 |
| Model 5 | |||
| HOMA-IR, per unit | 0.80 | 0.31–1.29 | 0.001 |
| Model 6 | |||
| Fasting glucose, per mmol/L (18 mg/dL) | 3.46 | 2.02–4.89 | <0.001 |
| Fasting insulin, per μU/mL | 0.08 | −0.05 to 0.21 | 0.230 |
| Model 7 | |||
| Fasting glucose, per mmol/L (18 mg/dL) | 3.28 | 1.78–4.78 | <0.001 |
| HOMA-IR, per unit | 0.36 | −0.16 to 0.89 | 0.177 |
All models except model 1 were adjusted for age, sex, weight, height, diastolic BP, current smoking, and the use of ACE inhibitors or ARB. Model 1 was adjusted for the same variables except for weight and height. GFR was measured by iohexol clearance and expressed as mL/min/1.73 m2.