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. 2011 Jun 17;34(7):1610–1616. doi: 10.2337/dc11-0091

Table 1.

Baseline clinical characteristics and other parameters in the study population

Variables Diabetes
Healthy
n = 18 n = 18 P
Age (years) 61 ± 4 67 ± 1 0.165
Sex NS
 Male 4 4
 Female 14 14
BMI (kg/m2) 32.3 ± 1.6 27.3 ± 1.4 0.024
Waist circumference (cm) 108 ± 4 93 ± 4 0.013
Fasting blood glucose (mg/dL) 120 ± 14 84 ± 3 0.016
Insulin (μU/mL) 17 ± 1 8 ± 1 0.001
HOMA-IR 5.00 ± 0.51 1.66 ± 0.24 0.001
Triglycerides (mg/dL) 100 ± 11 80 ± 9 0.157
HDL cholesterol (mg/dL) 51 ± 3 72 ± 4 0.002
Serum CML (units/mL) 17.4 ± 1.1 12 ± 0.5 0.001
Serum MG (nmol/mL) 2.6 ± 0.10 1.1 ± 0.06 0.001
Intracellular CML (units/mg) 7.9 ± 1.8 5.7 ± 2.3 0.005
Intracellular MG (nmol/mg) 0.87 ± 0.28 0.70 ± 0.38 0.148
8-Isoprostane (pg/mL) 234 ± 14 130 ± 11 0.033
Plasma leptin (ng/mL) 36 ± 3.6 15 ± 2.7 0.001
Plasma adiponectin (µg/mL) 7 ± 0.5 16 ± 2.6 0.004
AGER1 (mRNA) 133 ± 11 225 ± 28 0.011
RAGE (mRNA) 532 ± 77 464 ± 67 0.511
SIRT1 (mRNA) 282 ± 27 378 ± 27 0.029
p66shc (mRNA) 113 ± 20 66 ± 6 0.047
NOX p47phox (mRNA) 220 ± 24 125 ± 19 0.026
TNF-α (ng/mg protein in PMNCs) 18.5 ± 0.8 10 ± 0.5 0.001
Caloric intake (kcal/day) 2,329 ± 248 2,120 ± 215 0.934
AGE intake (AGE Eq/day) 23 ± 3 18 ± 1.3 0.135
Creatinine clearance* 92 ± 7 98 ± 4 0.431

Continuous data are expressed as mean ± SEM and categoric data as n. P values reflect differences between means of diabetic and healthy subjects at baseline. NS, not significant.

*Calculated as mL/min/1.73 m2.

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