Table 1.

Low testosterone is associated with increased mortality in older men

Study design	n	Follow-up (years)	Mortality	Hazard ratio (95% CI)	Recent studies
Retrospective	858	8	All-cause	1.88 (1.34–2.63)*	Shores et al. (42)
Prospective	794	20	All-cause and CVD	1.40 (1.14–1.71)* 1.38 (1.02–1.85)*	Laughlin et al. (45)
Prospective	2,314	10	All-cause and CVD	2.29 (1.60–3.26)*	Khaw et al. (43)
Prospective	1,954	7.2	All-cause and CVD	2.32 (1.38–3.89)*	Haring et al. (44)
Prospective	930	6.9	All-cause and CVD in men with CVD	2.27 (1.45–3.60)*	Malkin et al. (46)

*On the basis of recent publications in which the number of subject is >500 and age of the subjects is >60 years.