Table 1.
Characteristics of patients aged 30 to 85 years in THIN database. Values are numbers (percentages) unless stated otherwise
| Characteristics | Derivation cohort (QResearch) | External validation cohort (THIN) | ||||
|---|---|---|---|---|---|---|
| Women (n=1 183 663) | Men (n=1 174 232) | Women (n=1 136 417) | Men (n=1 108 219) | |||
| Median (interquartile range) age (years) | 48 (37-62) | 46 (37-59) | 48 (37-62) | 47 (37-59) | ||
| Alcohol consumption: | ||||||
| None | 275 984 (23.3) | 140 925 (12.0) | 243 624 (21.4) | 132 872 (12.0) | ||
| Trivial <1 unit/day | 341 295 (28.8) | 226 118 (19.3) | 288 754 (25.4) | 168 374 (15.2) | ||
| Light 1 or 2 units/day | 162 433 (13.7) | 234 460 (20.0) | 71 616 (6.3) | 72 962 (6.6) | ||
| Moderate 3-6 units/day | 19 455 (1.6) | 96 202 (8.2) | 17 911 (1.6) | 48 270 (4.4) | ||
| Heavy 7-9 units/day | 1208 (0.1) | 11 006 (0.9) | 1558 (0.1) | 7986 (0.7) | ||
| Very heavy >9 units/day | 1231 (0.1) | 8877 (0.8) | 1178 (0.1) | 5046 (0.5) | ||
| Not recorded | 382 063 (32.4) | 456 616 (38.9) | 511 776 (45.0) | 672 709 (60.7) | ||
| Body mass index: | ||||||
| Mean (SD) | 25.88 (4.9) | 26.43 (4.1) | 26.15 (5.0) | 26.63 (4.1) | ||
| Not recorded | 299 140 (25.3) | 392 613 (33.4) | 200 192 (17.6) | 270 900 (24.4) | ||
| Smoking status: | ||||||
| Non-smoker | 630 470 (53.3) | 462 344 (38.9) | 530 062 (46.6) | 401 760 (36.3) | ||
| Former smoker | 139 496 (11.8) | 173 503 (14.6) | 125 816 (11.1) | 158 600 (14.3) | ||
| Current smoker: | ||||||
| Light (<10 cigarettes/day) | 51 945 (4.4) | 69 504 (5.9) | 70 741 (6.2) | 68 077 (6.1) | ||
| Moderate (10-19 cigarettes/day) | 131 563 (11.1) | 146 959 (12.4) | 109 052 (9.6) | 104 844 (9.5) | ||
| Heavy (≥20 cigarettes/day) | 54 489 (4.6) | 77 147 (6.5) | 77 828 (6.9) | 117 567 (10.6) | ||
| Amount not recorded | 175 700 (14.8) | 244 775 (20.9) | 153 448 (13.5) | 137 617 (12.4) | ||
| Not recorded | 175 700 (14.8) | 244 775 (20.9) | 69 470 (6.1) | 119 754 (10.8) | ||
| Rheumatoid arthritis | 9459 (0.8) | 3903 (0.3) | 12 340 (1.1) | 5260 (0.5) | ||
| Cardiovascular disease | 41 842 (3.5) | 62 265 (5.2) | 54 520 (4.8) | 76 585 (6.9) | ||
| Type 2 diabetes | 22 645 (1.9) | 27 637 (2.3) | 28 039 (2.5) | 35 157 (3.2) | ||
| Asthma | 66 892 (5.7) | 55 888 (4.7) | 97 177 (8.6) | 78 079 (7.1) | ||
| Current tricyclic antidepressants | 46 054 (3.9) | 14 646 (1.2) | 59 803 (5.3) | 23 048 (2.1) | ||
| Current corticosteroids | 20 005 (1.7) | 11 569 (1.0) | 36 752 (3.2) | 23 686 (2.1) | ||
| History of falls | 8801 (0.7) | 4676 (0.4) | 29 106 (2.6) | 14 911 (1.4) | ||
| Chronic liver disease | 1563 (0.1) | 2133 (0.2) | 1892 (0.2) | 2586 (0.2) | ||
| Gastrointestinal malabsorption | 5970 (0.5) | 4851 (0.4) | 6388 (0.6) | 5047 (0.5) | ||
| Other endocrine conditions | 8615 (0.7) | 1886 (0.2) | 9665 (0.9) | 2124 (0.2) | ||
| Menopausal conditions | 25 683 (2.2) | — | 58 507 (5.2) | — | ||
| 10 year osteoporotic fracture risk (95% CI) | Not reported | Not reported | 3.04 (2.99 to 3.09) | 1.04 (1.01 to 1.07) | ||
| 10 year hip fracture risk (95% CI) | Not reported | Not reported | 1.48 (1.44 to 1.51) | 0.52 (0.50 to 0.54) | ||
| Country: | ||||||
| England: | Not reported | Not reported | 980 465 (86.3) | 956 465 (86.3) | ||
| Northern Ireland | Not reported | Not reported | 31 478 (2.8) | 29 428 (2.7) | ||
| Scotland | Not reported | Not reported | 61 563 (5.4) | 59 754 (5.4) | ||
| Wales | Not reported | Not reported | 62 911 (5.5) | 62 572 (5.7) | ||