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. 2011 May 20;10:20. doi: 10.1186/1476-0711-10-20

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Copyright ©2011 Tsuji et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pharmacodynamic relationship evaluating vancomycin concentration to minimum inhibitory concentration ratio (C:MIC) and change in log10 CFU/ml at 24 hours (Log Ratio Change) among agr functional HA-MRSA 7 (A,E), agr dysfunctional HA-MRSA 9 (B,F), agr functional CA-MRSA 26 (C,G), and agr dysfunctional CA-MRSA 20 (D,H) at low and high initial inoculum (10⁶, 10⁸log₁₀cfu/ml). R²: Coefficient of Determination. Data are reported as maximum likelihood model fitted parameter estimates from equation 2 for each strain.