Table 5.
Top ranking co-occurring domains in high confidence binding sites from human
| Domain Name A | Domain Name B | DOMINE |
|---|---|---|
| SH2 motif | Serine-threonine/tyrosine-protein kinase | Known |
| Serine-threonine/tyrosine-protein kinase | Insulin receptor substrate-1, PTB | Known |
| PDZ/DHR/GLGF | Cyclic AMP-dependent chloride channel | Novel |
| Serine-threonine/tyrosine-protein kinase | Phosphotyrosine interaction domain | Known |
| Serine-threonine/tyrosine-protein kinase | Serine-threonine/tyrosine-protein kinase | Known |
| PDZ/DHR/GLGF | Tyrosine-protein kinase, CSF-1/PDGF receptor | Novel |
| Src homology-3 domain | Serine/threonine-protein kinase-like domain | Known |
| SH2 motif | SH2 motif | Known |
| Src homology-3 domain | T-cell adhesion molecule CD2 | Novel |
| 7TM GPCR, rhodopsin-like | PDZ/DHR/GLGF | Known |
Binding sites included in this analysis had DM ≤ 0.20. Among interacting domain pairs in all sites, 22 out of 47 (46.8%) pairs are reported in the DOMINE database.