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. Author manuscript; available in PMC: 2012 Jun 8.
Published in final edited form as: Cell Metab. 2011 Jun 8;13(6):627–638. doi: 10.1016/j.cmet.2011.03.020

Figure 4. Ursolic Acid Induces Skeletal Muscle Hypertrophy.

Figure 4

Mice were provided ad lib access to either standard chow (control diet) or standard chow supplemented with 0.27% ursolic acid (ursolic acid diet) for 5 weeks before grip strength was measured and tissues were harvested. (A-C) Effect of ursolic acid on lower hindlimb muscle weight (A), quadriceps weight (B), and upper forelimb muscle (triceps and biceps) weight (C). Each data point represents one mouse, and horizontal bars denote the means. (D) Effect of ursolic acid on skeletal muscle fiber size distribution. Each distribution represents measurements of > 800 triceps muscle fibers from 7 animals (> 100 measurements / animal); P < 0.0001. (E) Effect of ursolic acid on peak grip strength, normalized to body weight. Each data point represents one mouse, and horizontal bars denote the means. Non-normalized grip strength data were 157 ± 9 g (control diet) and 181 ± 6 g (ursolic acid diet) (P = 0.04). See also Figure S2.