Table 1.
Overview of results: Symptoms association with cancer.
| Symptom | DOR* (95% CI*) | AUC** | Sensitivity (95% CI) | 1-specificity (95% CI) |
LR+ (95% CI) | LR- (95% CI) |
|---|---|---|---|---|---|---|
| Rectal bleeding# | 2.6 (1.9-3.6) p < 0.001 |
0.66 | 0.46 (0.38-0.55) |
0.25 (0.19-0.31). |
1.9 (1.5-2.3) |
0.7 (0.6-0.8) |
| Blood mixed with stool: |
3.1 (2.0-4.8) p < 0.001 |
0.68 |
0.49 (0.30-0.69) |
0.24 (0.13-0.40) |
2.1 (1.5-2.8) |
0.7 (0.5-0.9) |
| Blood: dark red |
3.9 (1.7 - 9.2) P = 0.004 |
0.71 |
0.29 (0.09-0.65) |
0.10 (0.03-0.28) |
3.1 (1.6-6.0) |
0.8 (0.6-1.1) |
| Change in bowel habit | 1.5 (0.8-2.8) p = 0.16 |
0.57 | 0.32 (0.21-0.46) |
0.24 (0.15-0.35) |
1.4 (0.9-2.1) |
0.9 (0.7-1.1) |
| Constipation | 1.1 (0.8-1.5) p = 0.48 |
0.52 | 0.12 (0.08-0.18) |
0.11 (0.07-0.16). |
1.1 (0.8-1.5) |
1.0 (1.0-1.0) |
| Diarrhoea | 0.9 (0.4-1.7) p = 0.65 |
0.47 | 0.15 (0.07-0.28) |
0.17 (0.09-0.29) |
0.9 (0.5-1.6) |
1.0 (0.9-1.1) |
| Abdominal pain | 0.7 (0.5-1.1) p = 0.12 |
0.45 | 0.19 (0.13-0.28) |
0.24 (0.17-0.33). |
0.8 (0.6-1.1) |
1.1 (1.0-1.2) |
| Weight loss | 2.9 (1.6-5.0) p = 0.001 |
0.67 | 0.20 (0.12-0.31) |
0.08 (0.05-0.13). |
2.5 (1.5-4.0) |
0.9 (0.8-1.0) |
*DOR = diagnostic odds ratio. No association between symptom and cancer if DOR = 1
**AUC = area under the Receiver operating characteristic curve. No association between symptom and cancer if AUC = 0.5
# Bleeding of any type
Note: Results for bleeding types for which there 3 or more papers or for which the DOR was > 1 are shown. Results for other bleeding types are shown in Additional File 4.