Table 3.
P53 target genes differentially expressed in melanoma cells with wild-type or mutant P53
| Accession No. | Gene Symbol | Gene Name | Fold change (WT vs MT) | p-value |
|---|---|---|---|---|
| NM_001012271.1 | BIRC5 | Baculoviral IAP repeat-containing 5 (Survivin), transcript variant 3 | 2.81 | 0.03297 |
| BIRC5 | 2.42 | 0.01001 | ||
| NM_001080125.1 | CASP8 | Caspase 8, transcript variant G | -5.88 | 0.02569 |
| NM_001024844.1 | CD82 | CD82 molecule, transcript variant 2 | -19.52 | 0.03576 |
| NM_001790.3 | CDC25C | Cell division cycle 25 homolog C, transcript variant 1 | -2.57 | 0.00007 |
| NM_058195.2 | CDKN2A | Cyclin-dependent kinase inhibitor 2A, transcript variant 4 | -88.58 | 0.0159 |
| CDKN2A | -34.08 | 2.2E-05 | ||
| NM_003068.3 | SNAI2/SLUG | Snail homolog 2 | -8.92 | 0.00005 |
| NM_005862.2 | STAG1 | Stromal antigen 1 | 2.33 | 0.04536 |
Fold change in mRNA expression of p53 target genes found to be significantly different in extracts from melanoma cell lines expressing wild-type p53 (IgR3, Mel-RM, MM200, Me1007) compared to melanoma cell lines with null/mutant p53 (Sk-Mel-28, Me4405) (> 2-fold difference, p ≤ 0.05 and FDR = 5.0%). Real-time qRT-PCR verification of selected genes is shown in italics.