Global brain synchronization as a function of discrete seizure frequency (# seizures per 2-hour window) during JIT control stimulation for each rat. The global synchronization is estimated within the corresponding 2-hour windows and illustrated in box-and-whisker box format (see text for details). A significant increase in brain synchronization (lowering of mean global T-index with increasing seizure frequency) is apparent in Rats 2, 3, and 6 only (panels b, c, and f), while no significant change in brain synchronization with seizure frequency is observed in Rats 1, 4 and 5 (panels a, d, and e).