Figure 3. mAb CC4 suppressed proliferation, migration and aggregation of colorectal cancer cells.

LS174T cells treated with indicated concentrations of mAb CC4 were subjected to proliferation assays using CFSE staining (A). The same assay was also performed using Lovo cells under the treatment of 25 µg/ml mAb CC4 (B). LS174T cells were used in migration assays using transwell system (C) and aggragation assays in the presence of indicated concentrations of mAb CC4 or normal mIgG (Di) with Ca²⁺ or EGTA (Dii). Statistically significant differences between mAb CC4 treated groups and control groups were indicated by double stars (**P<0.01).