TABLE IV.
Course 1 Non-Hematologic toxicities related to protocol therapy observed in 9 evaluable patients.
| Toxicity Type | Course 1 (total, 9 courses) | |||
|---|---|---|---|---|
| Grade 1 | Grade 2 | Grade 3 | Grade 4 | |
| Allergic reaction/hypersensitivity (including drug fever) | 1 | 2 | ||
| Hypotension | 1 | |||
| Fever (in the absence of neutropenia, where neutropenia is defined as ANC <1.0 × 10e9/L) |
3 | |||
| Rigors/chills | 1 | 4 | ||
| Rash/desquamation | 2 | |||
| Diarrhea | 1 | |||
| Febrile neutropenia (fever of unknown origin without clinically or microbiologically documented infection)(ANC <1.0 × 10e9/L, fever >=38.5 d |
1 | |||
| Hypoalbuminemia | 2 | |||
| ALT, SGPT | 1 | |||
| AST, SGOT | 1 | |||
| Hypocalcemia | 1 | |||
| Hypercalcemia | 1 | |||
| Hyperglycemia | 1 | |||
| Hypomagnesemia | 1 | |||
| Hypokalemia | 2 | |||
| Hypernatremia | 1 | |||
| Hyponatremia | 1 | |||
| Pain Buttock | 1 | |||
| Pain headache | 2 | |||
| PAIN NOS | 1 | |||
| Cough | 1 | |||
| Edema, larynx | 1 | |||
| Hypoxia | 1 | |||