Fig. 2.

Extinction of inhibitory avoidance memory was enhanced in the last trial of extinction (2 d after the last drug administration) in group 3 (n = 13; 10 mg/kg of topiramate twice daily at 9 am and 5 pm administered during the first 5 d of extinction procedure, p < 0.001) but not in group 2 (n = 13, 10 mg/kg of topiramate twice daily at 9 am and 5 pm administered for 2 wk before extinction, p = 0.07). We measured step-down latency in seconds and presented the results as medians and interquartile ranges (P₂₅ – P₇₅).