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. Author manuscript; available in PMC: 2012 Jul 1.

Published in final edited form as: Eur J Haematol. 2011 Jul;87(1):37–45. doi: 10.1111/j.1600-0609.2011.01615.x

Fig. 1B — Receiver operating characteristic curve (ROC) analysis. We define LDH ≥ 330 mg/dl (1.5x of normal upper limit) as abnormal. The aim is to evaluate the predictive value of PNH to discriminate normal and abnormal LDH. The area under the ROC curve (AUC) is 0.96 for erythrocyte PNH and is 0.88 for granulocyte PNH. The erythrocyte PNH size of 3~5% and granulocyte PNH size of 23% are the optimal threshold at which the PNH clone sizes can best classify patients as with and without hemolysis.

Fig. 1B — Receiver operating characteristic curve (ROC) analysis. We define LDH ≥ 330 mg/dl (1.5x of normal upper limit) as abnormal. The aim is to evaluate the predictive value of PNH to discriminate normal and abnormal LDH. The area under the ROC curve (AUC) is 0.96 for erythrocyte PNH and is 0.88 for granulocyte PNH. The erythrocyte PNH size of 3~5% and granulocyte PNH size of 23% are the optimal threshold at which the PNH clone sizes can best classify patients as with and without hemolysis.