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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Eur J Haematol. 2011 Jul;87(1):37–45. doi: 10.1111/j.1600-0609.2011.01615.x

Table 2.

Clinical characteristics of the cohort.

Patient Sex/Age (yrs) Initial Diagnosis Follow-up (mos) PNH size (%) (initial/current)* LDH (mg/dl) (initial/current) Therapy Post-treatment AA status
1 F/41 SAA 114 0.5 /0.2 87/ 98 HiCy Remission
2 F/22 SAA 129 0.16/50 186/628 HiCy Remission for 108 mos, then transformed to PNH
3 F/68 vSAA 86 22/0.18 178/172 HiCy Remission
4 F/15 SAA 87 24 /31 382/527 HiCy Remission for 84 mos, then transformed to PNH
5 M/37 SAA 78 12.3 / 14 390/501 HiCy Remission
6 M/9 SAA 109 66.5/96.7 536/507 HiCy Remission for 60 mos, then asymptomatic PNH expansion
7 F/19 SAA 63 0.1/38 181/447 HiCy Remission
8 F/19 SAA 52 0.12/23 193/285 HiCy Remission for 52 mos, then AA relapse
9 M/22 SAA 50 5/0.8 198/162 HiCy Remission
10 M/36 SAA 49 31/3.9 171/190 HiCy Remission
11 M/20 SAA 37 0.06/1 200/ 269 HiCy Remission
12 F/32 SAA 38 51.67/40.7 237/191 HiCy Remission with asymptomatic PNH expansion
13 M/20 SAA 18 0.34/ 0.46 180/ 172 HiCy Remission
14 M/24 SAA 30 17/ 84 302/ 912 HiCy AA relapse after 3 mos remission, then transformed to PNH after 18 mos
15 F/52 SAA 39 23/72 314/229/188 HiCy, then BMT Refractory, then remission post BMT
16 F/34 SAA 138 0.14/3 235/182 CSA, then HiCy AA relapse after 6 mos remission, then remission again post HiCy
17 F/18 vSAA 123 6/ 26 147/ 266 Prednisone, then HiCy Refractory, then remission post HiCy
18 F/10 SAA 134 0.02 / 0 178/208 ATG/CSA, then HiCy AA relapse after 30 mos remission, then remission again post HiCy
19 F/31 SAA 82 57 / 62.2 267/ 395 ATG/CSA, then HiCy Refractory, then remission post HiCy
20 M/41 SAA 81 0.12/1 174/ 171 ATG/CSA, then HiCy twice AA relapse after 7 mos remission, then relapse again 72 mos after HiCy, then remission again post second HiCy
21 F/62 SAA 60 15/6.2 189/189 CSA, then HiCy Refractory, then remission post HiCy
22 F/19 SAA 49 60/1 353/ 306 CSA, then HiCy Refractory, then remission post HiCy
23 F/46 NSAA 131 0.5 /6 223/ 235 CSA Remission
24 F/27 SAA 38 17/50 307/ 600 ATG/CSA Remission for 30 mos, then asymptomatic PNH expansion
25 M/39 NSAA 84 0.3/1.5 206/231 No treatment Self recovery
26 F/17 NSAA 56 15/4.2 419/ 189 No treatment Self recovery
27 F/48 NSAA 36 25/51 512/ 606 No treatment Asymptomatic PNH expansion

Remission was classified as HCT ≥30%/independence of transfusion/ANC≥500/cumm/Platelet count≥20K/cumm. PNH transformation was classified as presenting classical PNH symptoms and developing apparent hemolysis with LDH value >1.5x of normal upper limit.

*

initial PNH size means the PNH size before treatment, and current PNH size means the PNH size in the most recent visit.