Table 3.
Multivariate model of Cox and log normal regression with prognostic factors (full model and final model)
|
Cox HR (95% CI) |
Log normal HR (95% CI) |
|||
| Full model (AIC = 1508.49) | Final model (AIC = 2534.72) | Full model (AIC = 913.34) | Final model (AIC = 1693.56) | |
| Sex | ||||
| Male | 0.91 (0.801-1.034) | 0.886 (0.781-1.005) | ||
| Female | 1.00 | |||
| Age at diagnosis | 1.0141 (1.009-1.02) | 1.0111 (1.006-1.017) | 1.0151 (1.010-1.021) | 1.0151 (1.009-1.020) |
| Past history | ||||
| Without | 1.00 | 1.00 | 1.00 | 1.00 |
| With | 0.8401 (0.738-0.955) | 0.8581 (0.755-0.975) | 0.8131 (0.716-0.914) | 0.8091 (0.713-0.919) |
| Family history | ||||
| Without | 1.00 | 1.00 | 1.00 | |
| With | 0.957 (0.8254-1.11) | 0.967 (0.833-1.234) | ||
| Cancer number | ||||
| Single | 1.00 | 1.00 | ||
| Multiple | 1.21 (0.861-1.701) | 1.312 (1.935-1.840) | ||
| Cancer location | ||||
| Lower third | 1.00 | 1.00 | 1.00 | |
| Middle third | 1.033 (0.885-1.205) | 1.1351 (1.073-1.199) | 1.1291 (1.069-1.194) | |
| Upper third | 1.4061 (1.173-1.686) | 1.2881 (1.224-1.353) | 1.2771 (1.211-1.338) | |
| Total stomach | 1.4661 (1.214-1.771) | 1.4621 (1.365-1.558) | 1.4391 (1.343-1.535) | |
| Distant metastasis | ||||
| Absent | 1.00 | 1.00 | 1.00 | |
| Present | 1.211 (1.013-1.447) | 1.2051 (1.011-1.437) | 1.1981 (1.009-1.424) | |
| Surgical curative degree | ||||
| Absolutely radical | 1.00 | 1.00 | 1.00 | 1.00 |
| Relatively radical | 1.3891 (1.197-1.611) | 1.3831 (1.194-1.601) | 1.7241 (1.537-1.934) | 1.6721 (1.538-1.817) |
| Palliative | 3.8891 (2.583-5.855) | 2.6871 (2.316-3.116) | 2.9721 (2.770-3.174) | 2.7961 (2.653-2.938) |
| Lymph node dissection | ||||
| > D2 | 1.00 | 1.00 | ||
| D2 | 0.908 (0.784-1.051) | 0.967 (0.892-1.049) | ||
| D1 | 0.901 (0.712-1.14) | 0.935 (0.855-1.015) | ||
| < D1 | 0.6071 (0.395-0.935) | 0.904 (0.784-1.024) | ||
| Combined other organ resection | ||||
| Without | 1.00 | 1.00 | ||
| With | 1.4061 (1.227-1.61) | 1.4471 (1.264-1.657) | ||
| Histologic types | ||||
| Well differentiated | 1.00 | 1.00 | 1.00 | |
| Middle differentiated | 1.056 (0.878-1.271) | 1.1101 (1.042-1.183) | 1.1201 (1.051-1.193) | |
| Poor differentiated | 1.1791 (1.035-1.343) | 1.2321 (1.160-1.304) | 1.2541 (1.182-1.327) | |
| Borrmann classification | ||||
| I | 1.00 | 1.00 | 1.00 | 1.00 |
| II | 1.142 (0.957-1.319) | 1.201 (1.068-1.433) | 1.018 (0.943-1.106) | 1.015 (0.941-1.102) |
| III | 1.3151 (1.113-1.672) | 1.3941 (1.205-1.741) | 1.2461 (1.052-1.539) | 1.2411 (1.047-1.533) |
| IV | 2.1261 (1.758-3.119) | 2.2531 (1.827-3.284) | 2.5301 (2.376-2.713) | 2.5261 (2.372-2.708) |
| Lauren classification | ||||
| Intestinal type | 1.00 | 1.00 | 1.00 | |
| Diffuse type | 1.1311 (1.012-1.358) | 1.3071 (1.154-1.528) | 1.3021 (1.148-1.523) | |
| pT stage | ||||
| pT1 | 1.00 | 1.00 | 1.00 | 1.00 |
| pT2 | 1.8511 (1.431-2.394) | 1.9711 (1.528-2.542) | 1.1951 (1.102-1.297) | 1.1931 (1.100-1.294) |
| pT3 | 1.9811 (1.511-2.598) | 2.191 (1.678-2.858) | 1.4281 (1.328-1.527) | 1.4231 (1.324-1.522) |
| pT4 | 2.3441 (1.699-3.235) | 2.5011 (1.821-3.435) | 1.7061 (1.557-1.855) | 1.6971 (1.549-1.847) |
| Total dissected nodes | 0.9871 (0.981-0.993) | 0.9881 (0.982-0.993) | ||
| pN stage | ||||
| pN0 | 1.00 | 1.00 | 1.00 | 1.00 |
| pN1 | 1.2811 (1.123-1.461) | 1.2661 (1.11-1.444) | 1.5071 (1.393-1.620) | 1.5001 (1.387-1.622) |
| pN2 | 2.1391 (1.783-2.566) | 2.0951 (1.749-2.51) | 2.2711 (2.151-2.391) | 2.2501 (2.130-2.370) |
| pN3 | 3.241 (2.446-4.292) | 3.3251 (2.52-4.386) | 3.4221 (3.242-3.602) | 3.3751 (3.196-3.554) |
1
Statistically significant (< 0.05); HR: Hazard radio; CI: Confidence interval; AIC: Akaike Information Criterion.