Fig. 1.

Identification of RT1.B^L-peptide-binding motifs of rat AQP-4. a List of amino acids enhancing or decreasing binding to RT1.B^L at peptide positions 1–9 [39]. Please note that positions 4 and 5 do not play an important role in RT1.B^L binding [39] and were neglected in peptide search. b Amino acid sequences of two rat AQP-4 nonamers showing a 100% match to the binding requirements at positions 1,3,7,8, and 9 (red), and of seven rat aquaporin 4 nonamers showing 1 mismatch (green) to the optimal binding motif at these positions. c Alignment of the completely matching epitopes with rat aquaporin 4