Fig. 9.
Alignment of the amino acid sequence of RT1.BL binding T cell epitopes of rat AQP-4 with other known AQPs. The following accession numbers were used to align sequences: AQP-1 (EDL88090.1), AQP-2 (NP_037041.2), AQP-3 (NP_113891.1), AQP-4 (NP_001135838.1), AQP-5 (NP_036911.1), AQP6 (NP_071517.1), AQP-8 (NP_062031.1), AQP-9 (NP_075249.1), AQP-12 (NP_001102479.1). a Alignment of AQP-4220–228. The amino acid sequence of AQP-4220–228 (red) is unique among all AQPs studied. All other AQP sequences have either amino acid mismatches (black) or insertions (small letters) at this site. b Alignment of AQP-4296–304. The amino acid sequence of AQP-4296–304 (red) is unique among all AQPs studied. All other sequences have either no significant similarity (−), or just an arbitrary match of four amino acid within their sequence (AQP-3)