. Author manuscript; available in PMC: 2011 Jun 23.

Published in final edited form as: Clin Appl Immunol Rev. 2003 Jul;4(1):3–14. doi: 10.1016/S1529-1049(03)00007-2

Table 1.

Immune cell binding and modulation by Anti-P-gp antibodies

Anti-P-gp antibody	Epitope site	Reported function	References
MRK16	External	Blocks migration of mononuclear phagocytes	[44]
		Staining CD56⁺ > CD8⁺, CD4⁺ and CD19⁺ cells > CD14⁺ cells. No staining of CD15⁺ cells	[30]
		Staining of 55–65% of the lymphoid bone marrow cells, correlated with dye retention	[16]
		Expression on CD8⁺ > CD4⁺ cells. Inhibits T cell cytotoxic function	[33]
		Blockade induces decreased IL-2 levels, but not IL-2 mRNA	[36]
		Inhibits NK cell-mediated cytotoxicity	[47]
UIC2	External	Blocks migration of mononuclear phagocytes	[44]
		Staining of 55–65% of the lymphoid bone marrow cells; correlation with dye retention	[16]
		Inhibits IL-2, IL-4, IFN-γ not IL-6	[35]
		Decreases IL-2 levels but not IL-2 mRNA	[36]
Hyb241	External	Inhibits alloimmune IL-2, IFN-γ and TNF-α and IL-12 production via both APC and CD4⁺ dependent pathways	[31]
4E3	External	In CD8⁺ cells, 4E3 is more specific for P-gp than MRK16	[34]
		Blocks transendothelial migration of mononuclear phagocytes	[44]
C219	Internal	Staining of CD4⁺, CD8⁺, CD14⁺, CD19⁺, CD56⁺ cells, not granulocytes	[19]