. Author manuscript; available in PMC: 2012 Jul 1.

Published in final edited form as: Magn Reson Med. 2011 Feb 24;66(1):40–56. doi: 10.1002/mrm.22775

Table 3.

MR constants and physiological parameters used in the simulations.

	T₁ (ms)	T₂ (ms)		C (ml water /ml tissue)	X (%)	CBV (ml blood /ml parenchyma)
	T₁ (ms)	base.	act.	C (ml water /ml tissue)	X (%)	base.	act.
GM	1209^a	70.8^c	71.4^c	0.89^e	84.5^c	0.0525^c	0.0655^f
WM	758^a	81^a	81^a	0.73^e	5^c	0.0210^c	0.0210^c
CSF	4300^a	1442^c	1442^c	1^c	10.5^c
Arterial blood	1627^b	102^d	102^d	0.87^e		0.0110^g	0.0176^h
Capillary blood	1627^b	63.3^d	80.1^d	0.87^e		0.0173^g	0.0208^h
Venous blood	1627^b	36.2^d	55.3^d	0.87^e		0.0242^g	0.0271^h

Lu et al. (62).

Lu et al. (32). No significant difference was found between arterial and venous blood.

Donahue et al. (19). The GM T₂ values are for extravascular tissue only, not including the blood compartment.

Zhao et al. (63), based on oxygenation levels at baseline/activation of: arterial = 98%/98%, capillary = 77%/85%, venous = 61%/73%.

Herscovitch et al. (64).

A 25% total CBV change is assumed.

Volume fractions: arteriolar, capillary, venular = 21%, 33%, 46%, are assumed (36,37).

A 60% increase in CBV_a (4), a 20% increase in CBV_c (33,34), and the remaining 12% increase in CBV_v are assumed.