Figure 1.

Protein interaction networks constructed by DEGs in psoriasis. The node indicates protein and the edge indicates protein-protein interaction. The red nodes are essential enzymes predicted by topological metrics such as degree and betweenness centrality. (a) Protein interaction network constructed from genes upregulated in microarray data from regions with and without lesions in psoriasis patients. The network consisted of 1,310 proteins and 1,934 interactions. (b) Protein interaction network constructed from downregulated genes. The network consisted of 985 proteins and 1,205 interactions.