Table 1.
Selected hub proteins in the protein interaction network constructed from upregulated genes.
| Gene symbol | Refseq ID | Full name (enzyme number) | Topological metrics |
|---|---|---|---|
| CDKN1A | NP_000380.1 | Cyclin dependent kinase inhibitor 1A | centrality: 64419 |
| RUVBL2 | NP_006657.1 | RuvB like 2 (3.6.4.12: DNA helicase) | centrality: 50925 |
| COPS6 | NP_006824.2 | COP9 constitutive photomorphogenic homolog subunit 6 | centrality:60596 |
| EWSR1 | NP_001156757.1 | Ewing sarcoma breakpoint region 1 | centrality: 62682 |
| FTSJ1 | NP_036412.1 | FtsJ homolog 1 | degree: 27 |
| SFN | NP_006133.1 | 14-3-3 sigma | centrality: 50372 |
| GRB2 | NP_002077.1 | Grb2 | centrality: 397096 |
| CCDC85C | NP_001138467.1 | C14orf65 protein | centrality: 76862 |
| EIF6 | NP_002203.1 | Eukaryotic translation initiation factor 6 | centrality: 61909 |
| ARF6 | NP_001654.1 | ADP ribosylation factor 6 | centrality: 45220 |
| NFKB1 | NP_001158884.1 | NFKB1 | degree: 18 |
| PCNA | NP_002583.1 | Proliferating cell nuclear antigen | centrality: 46316 |
| PINX1 | NP_060354.4 | Pin2 interacting protein X1 | centrality: 51027 |
| PSMA2 | NP_002778.1 | Proteasome subunit alpha type 2 (3.4.25.1: Proteasome endopeptidase complex) | degree: 17 |
| VDAC1 | NP_003365.1 | VDAC1 | degree: 18 |
| ZAP70 | NP_001070.2 | ZAP70 (2.7.10.2: Nonspecific protein-tyrosine kinase) | centrality: 50140 |
| IKBKE | NP_001180250.1 | IKKE (2.7.11.10: I-kappa-B kinase) | centrality: 412760 |