Table 2.
Selected hub proteins in the protein interaction network constructed from downregulatedgenes.
| Gene symbol | Refseq ID | Full name (enzyme number) | Topological metrics |
|---|---|---|---|
| EIF1B | NP_005866.1 | Translation factor sui1 homolog | centrality: 41540 |
| RNPS1 | NP_006702.1 | RNA binding protein S1, serine-rich domain | degree: 21 |
| EGFR | NP_005219.2 | EGF receptor (2.7.10.1: Receptor protein-tyrosine kinase) | centrality: 83945 |
| NINL | NP_079452.3 | KIAA0980 protein | centrality: 53502 |
| HTT | NP_002102.4 | Huntingtin | centrality: 99972 |
| HMGB1 | NP_002119.1 | High mobility group box 1 | centrality: 43032 |
| APP | NP_000475.1 | Amyloid beta A4 protein | centrality: 51716 |
| RIF1 | NP_001171134.1 | Rap1 interacting factor 1 | degree: 17 |
| PLSCR4 | NP_001121778.1 | Phospholipid scramblase 4 | centrality: 60954 |
| BCL6 | NP_001124317.1 | B cell lymphoma 6 protein | degree: 18 |
| TBP | NP_001165556.1 | TATA box binding protein | centrality: 40738 |
| SUMO1 | NP_001005781.1 | SMT3 suppressor of mif two 3 homolog 1 | degree: 21 |
| UNC119B | NP_001074002.1 | Unc-119 homolog B | centrality: 42366 |
| NCOR1 | NP_001177367.1 | Nuclear receptor corepressor 1 | degree: 16 |
| UTP14C | NP_067677.4 | UTP14, U3 small nucleolarribonucleoprotein, homolog C | centrality: 60679 |