Table 3.
Nonsynonymous SNPs of ZAP70.
| rsNumber | DNA substitution | Amino-acid substitution | Overall stability | Predicted ΔΔG (kcal/mol) |
|---|---|---|---|---|
| rs56077145 | 106C > G | Leu36Val | Destabilising | −1.03 |
| rs113994172 | 239C > A | Pro80Gln | Stabilising | 0.82 |
| rs56264206 | 308A > T | Asn103Ile | Stabilising | 0.71 |
| rs55845489 | 309C > A | Asn103Lys | Destabilising | −0.36 |
| rs55679020 | 311G > C | Arg104Pro | Stabilising | 0.11 |
| rs111771234 | 550T > A | Phe115Ile | Stabilising | 0.67 |
| rs55964305 | 524G > T | Arg175Leu | Destabilising | −0.67 |
| rs56403250 | 572C > T | Pro191Leu | Stabilising | 0.08 |
| rs76059124 | 653C > T | Ala218Val | Destabilising | −1.86 |
| rs113310375 | 1274T > C | Val356Ala | Destabilising | −2.01 |
| rs113994174 | 1393C > T | Arg465Cys | Destabilising | −0.81 |
| rs56059280 | 1468G > A | Asp490Asn | Destabilising | −0.29 |
| rs104893674 | 1554C > A | Ser518Arg | Destabilising | −0.56 |
| rs56189815 | 1568G > T | Trp523Leu | Stabilising | 3.36 |
| rs56146954 | 1580T > G | Val527Gly | Destabilising | −4.09 |
| rs113994175 | 1714A >T | Met572Leu | Stabilising | 0.17 |
| rs55803111 | 1781G > A | Arg594Gln | Stabilising | 1.11 |
| rs56326640 | 1783G > T | Ala595Ser | Destabilising | −0.36 |
| rs56250717 | 1826G > A | Gly609Asp | — | — |