Table 1.
Relationships between glycosyltransferase expression, network, and glycan signature
| Glycosyltransferase | Functions | Glycan structure |
|---|---|---|
| ST6GAL1 | N-, O-Glycan and glycolipid biosynthesis | Siaa2,6Galb1,4GlcNAc-R |
| B3GNT3 | O-Glycan biosynthesis | core1 extension |
| GCNT2 | N-, O-Glycan and glycolipid biosynthesis | I antigen Siaa2,3Galb1,3GalNAca1- |
| ST3GAL1 | O-Glycan biosynthesis | Ser/Thr |
| FUT2 | N-, O-Glycan and glycolipid biosynthesis | H antigen |
| GALNT6 | O-Glycan biosynthesis | GalNAca1-Ser/Thr |
| GALNT8 | O-Glycan biosynthesis | GalNAca1-Ser/Thr |
| GALNT10 | O-Glycan biosynthesis | GalNAca1-Ser/Thr |
| GALNT12 | O-Glycan biosynthesis | GalNAca1-Ser/Thr |
| GALNT14 | O-Glycan biosynthesis | GalNAca1-Ser/Thr |
| GALNTL2 | Unknown | |
| B3GALT5 | N-, O-Glycan and glycolipid biosynthesis | Galb1,3GlcNAc-R, SSEA-3 |
| B3GALT1 | N-, O-Glycan and glycolipid biosynthesis N- and O-Glycan, keratan sulfate | Galb1,3GlcNAc-R |
| B3GNT2 | biosynthesis | polylactosamine |
The fourteen glycosyltransferases with identified correspondences between expression, network, and glycan signatures were allocated to biosynthetic pathways, using the KEGG GLYCAN database with modifications. The names of the pathways are listed. See also additional file 12 for the detailed pathways of notable glycosyltransferases, according to the KEGG GLYCAN database.