Table 3. Sensitivity, Specificity, and Positive and Negative Predictive Values of Echocardiographic Findings for Diagnosis of PH in Children <2 Years of Age With CLD.
| Finding | Mean (95% CI), % | |||
|---|---|---|---|---|
| Sensitivity | Specificity | Positive Predictive Value | Negative Predictive Value | |
| Estimated sPAP of >40 mm Hg (n = 19) | 88 (64–97) | 33 (6–79) | 88 (64–97) | 33 (6–79) |
| Right atrial enlargement | ||||
| All (n = 31) | 80 (61–91) | 50 (19–81) | 87 (68–94) | 38 (14–69) |
| With measurable TRJV (n = 19) | 94 (72–99) | 67 (21–94) | 94 (72–99) | 67 (21–94) |
| Without measurable TRJV (n = 12) | 56 (27–81) | 33 (6–79) | 71 (36–92) | 20 (4–62) |
| Right ventricular dilation | ||||
| All | 84 (66–93) | 50 (19–81) | 88 (69–96) | 43 (16–75) |
| With measurable TRJV | 94 (72–99) | 67 (21–94) | 94 (72–99) | 67 (21–94) |
| Without measurable TRJV | 67 (37–86) | 33 (6–79) | 75 (41–93) | 25 (5–70) |
| Right ventricular hypertrophy | ||||
| All | 72 (52–86) | 83 (44–97) | 95 (75–99) | 42 (19–68) |
| With measurable TRJV | 81 (57–93) | 100 (44–100) | 100 (77–100) | 50 (19–81) |
| Without measurable TRJV | 56 (27–81) | 67 (21–94) | 83 (44–97) | 33 (10–70) |
| PA dilation | ||||
| All | 52 (33–70) | 50 (19–81) | 81 (57–93) | 20 (7–45) |
| With measurable TRJV | 50 (28–72) | 33 (6–79) | 80 (49–94) | 11 (2–44) |
| Without measurable TRJV | 56 (27–81) | 67 (21–94) | 83 (44–97) | 33 (10–70) |
| Septal flattening | ||||
| All | 88 (70–96) | 33 (10–70) | 85 (66–94) | 40 (12–77) |
| With measurable TRJV | 100 (81–100) | 33 (6–79) | 89 (67–97) | 100 (21–100) |
| Without measurable TRJV | 67 (35–88) | 33 (6–79) | 75 (41–93) | 25 (5–70) |
| ≥1 abnormality | ||||
| All | 96 (81–99) | 33 (10–70) | 86 (69–94) | 67 (21–94) |
| With measurable TRJV | 100 (81–100) | 33 (6–79) | 89 (67–97) | 100 (21–100) |
| Without measurable TRJV | 86 (50–96) | 20 (4–62) | 60 (31–83) | 50 (9–91) |
| ≥2 abnormalities | ||||
| All | 88 (70–96) | 33 (10–70) | 85 (66–94) | 40 (12–77) |
| With measurable TRJV | 94 (72–99) | 33 (6–79) | 88 (66–97) | 50 (9–91) |
| Without measurable TRJV | 71 (38–90) | 20 (4–62) | 56 (27–81) | 33 (6–79) |
| ≥3 abnormalities | ||||
| All | 84 (66–94) | 50 (19–81) | 88 (69–96) | 43 (16–75) |
| With measurable TRJV | 94 (72–99) | 67 (21–94) | 94 (72–99) | 67 (21–94) |
| Without measurable TRJV | 57 (27–82) | 20 (4–62) | 50 (22–78) | 25 (5–70) |
The standard comparison for diagnosis of PH was mPAP of >25 mm Hg measured with cardiac catheterization.