Table 2.
Baseline and Follow-up Liver Enzyme Test Results
| All Patients | Without a Liver Diagnosis1 | |||||
|---|---|---|---|---|---|---|
| N | Median (IQR) | Abnormal (%)2 | N | Median (IQR) | Abnormal (%)2 | |
| Baseline | 299 | 182 | ||||
| ALT (IU/L) | 29 (22, 44) | 30 (10.0%) | 27 (21, 39) | 14 (7.7%) | ||
| AST (IU/L) | 28 (24, 36) | 50 (16.7%) | 27 (23, 34) | 24 (13.2%) | ||
| Alkaline phosphatase (IU/L) | 74 (59, 89) | 11 (3.7%) | 74 (59, 90) | 10 (5.5%) | ||
| Any of the above | 59 (19.7%) | 31 (17.0%) | ||||
| Follow-up (median 6 months) | 215 | 134 | ||||
| ALT (IU/L) | 27 (21, 35) | 9 (4.2%) | 26 (21, 32) | 3 (2.2%) | ||
| AST (IU/L) | 28 (24, 33) | 16 (7.4%) | 27 (23, 33) | 8 (6.0%) | ||
| Alkaline phosphatase (IU/L) | 72 (59, 85) | 2 (0.9%) | 72 (58, 85) | 0 (0.0%) | ||
| Any of the above | 21 (9.8%) | 10 (7.5%) | ||||
| Maximum of both visits | 299 | 182 | ||||
| ALT (IU/L) | 39 (13.0%) | 17 (9.3%) | ||||
| AST (IU/L) | 66 (22.1%) | 32 (17.6%) | ||||
| Alkaline phosphatase (IU/L) | 13 (4.3%) | 10 (5.5%) | ||||
| Any of the above | 80 (26.8%) | 41 (22.5%) | ||||
| Grade 1 | 77 (25.8%) | 39 (21.4%) | ||||
| Grade 23 | 5 (1.7%) | 3 (1.6%) | ||||
1
Excludes patients with hepatitis B or C, excessive alcohol use, NAFLD, or other known liver disease.
2
Abnormal liver enzyme tests were defined as follows: ALT > 63 IU/L; AST > 41 IU/L; alkaline phosphatase > 126.
3
There were no grade 3 or 4 abnormalities.